Bromocriptine and insulin secretion.
نویسندگان
چکیده
The dopaminergic drug bromocriptine inhibited the release of insulin from isolated mouse pancreatic islets. The effect was counteracted by haloperidol or pimozide. It is suggested that insulin release may be inhibited through activation of D-2 dopaminergic receptors in the pancreatic beta-cells.
منابع مشابه
The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha2-adrenergic receptors in beta cells.
Treatment with the dopamine receptor D2 (DRD2) agonist bromocriptine improves metabolic features in obese patients with type 2 diabetes by a still unknown mechanism. In the present study, we investigated the acute effect of bromocriptine and its underlying mechanism(s) on insulin secretion both in vivo and in vitro. For this purpose, C57Bl6/J mice were subjected to an intraperitoneal glucose to...
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Thyrotropine secretion in human beings is under the influence of various factors. The effect of the hormones, triiodothyronine, thyroxine, somatostatin and thyroid-stimulating hormone has been well known. In this study the direct effect of stimulation of the dopaminergic system by bromocriptine on the thyrotropine secretion was investigated. In this study twenty women with hyperprolactinemia r...
متن کاملBromocriptine: A Sympatholytic, D2-Dopamine Agonist for the Treatment of Type 2 Diabetes
B romocriptine is a sympatholytic D2-dopamine agonist that has been approved for the treatment of type 2 diabetes. Based on animal and human studies, timed bromocriptine administration within 2 h of awakening is believed to augment low hypothalamic dopamine levels and inhibit excessive sympathetic tone within the central nervous system (CNS), resulting in a reduction in postmeal plasma glucose ...
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عنوان ژورنال:
- Bioscience reports
دوره 2 2 شماره
صفحات -
تاریخ انتشار 1982